UJI AKTIVITAS ANTIPIRETIK EKSTRAK ETANOL DAUN SAWI PAKCOY (Brassica rapa Linn.) TERHADAP MENCIT PUTIH (Mus musculus L.) JANTAN YANG DI INDUKSI PEPTON 5%

Abstract

Fever is a condition marked by an increase in body temperature beyond normal

limits. This study aims to evaluate the antipyretic effect of ethanol extract from

pakcoy mustard leaves (Brassica rapa Linn.) on male white mice (Mus musculus

L.) induced with 5% peptone and to determine the effective dose of the extract.

Fifteen male mice were divided into five groups: negative control (0.5% Na-CMC),

positive control (paracetamol 65 mg/kg body weight), and three treatment groups

receiving ethanol extract doses of 100 mg/kg, 200 mg/kg, and 400 mg/kg body

weight. All groups were induced using 5% peptone subcutaneously until a rectal

temperature increase of ≥0.6°C occurred, followed by oral administration of the

test substances. Temperature was recorded every 30 minutes over 4 hours.

Statistical analysis revealed significant antipyretic effects in all treatment groups

compared to the negative control (p values 0.02, 0.01, 0.04; p < 0.05) at doses 100,

200, and 400 mg/kg body weight respectively. The findings suggest that ethanol

extract of pakcoy mustard leaves possesses significant antipyretic activity in male

white mice induced with fever.

Keywords: Pakcoy Mustard (Brassica rapa Linn.), Antipyretic, White Mice (Mus

musculus L.)