UJI AKTIVITAS ANTIHIPERURISEMIA EKSTRAK ETANOL DAUN BUNI (Antidesma bunius L.) PADA MENCIT PUTIH (Mus musculus L.) JANTAN

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Published: Mar 2, 2026

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Sulastri Herdaningsih
a:1:{s:5:"en_US";s:31:"Akademi Farmasi Yarsi Pontianak";}
Khizul Hertiani
akademi farmasi YARSI Pontianak

Abstract

Hyperuricemia is a condition characterized by elevated levels of uric acid in the blood, which can lead to diseases such as gout arthritis. This study aims to evaluate the activity and effective dose of ethanolic extract of buni leaves as ananti-hyperuricemic agent in male white mice (Mus musculus L.) induced with potassium oxonate and chicken liver juice. A total of 25 mice were divided into five groups: positive control (allopurinol 100 mg/kgBW), negative control (0.5% Na-CMC), and three test groups receiving buni leaf extract at doses of 50 mg/kgBW, 75 mg/kgBW, and 100 mg/kgBW,respectively. Uric acid levels were measured over a period of 4 hours after treatment. The results showed that the positivecontrol group and all groups treated with buni leaf extract at doses of 50, 75, and 100 mg/kg BW exhibited antihyperuricemic activity, as indicated by a significant difference compared to the negative control group (p<0.05). Thepercentage of antihyperuricemic activity reached 100% in the positive control group and all buni leaf extract groups. It can thus be concluded that the ethanolic extract of buni leaves has potential as an antihyperuricemic agent.


Keywords: Buni leaves (Antidesma bunius L.), anti-hyperuricemia, uric acid, mice (Mus musculus).

Article Details

How to Cite
Herdaningsih, S., & Hertiani, K. . (2026). UJI AKTIVITAS ANTIHIPERURISEMIA EKSTRAK ETANOL DAUN BUNI (Antidesma bunius L.) PADA MENCIT PUTIH (Mus musculus L.) JANTAN. Jurnal Komunitas Farmasi Nasional, 5(02). Retrieved from https://jkfn.akfaryarsiptk.ac.id/index.php/jkfn/article/view/225
Issue
Vol. 5 No. 02 (2025): Jurnal Komunitas Farmasi Nasional
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Articles
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References

Alyah, R. (2024). Efektivitas Ekstrak Etanol Daun Buni (Antidesma bunius L.) Terhadap Kadar Gula Darah Pada Tikus Putih Jantan (Rattus norvegicus) Yang Diinduksi Streptozotocin. Skripsi. Universitas Muhammadiyah Makasar. Makasar.

Dewi, I. S., Saptawati, T., & Rachma, F. A. (2021). Skrining Fitokimia Ekstrak Etanol Kulit dan Biji Terong Belanda (Solanum betaceum Cav.) Phytochemical Screening of Tamarillo Peel and Seeds Ethanol Extracts (Solanum Betaceum Cav.). Prosiding Seminar Nasional UNIMUS, 4, 1210–1218.

Dewi, S. R., Wahyuningsih, E. S., & Gunarti, N. S. (2023). Literatur Riview : Telaah Pengobatan Modern Dan Tradisonal Pada Penyakit Asam Urat (Gout). Jurnal Buana Farma, 3(4), 141–153.

Elisa, G., Nainggolan, M., & Haro, G. (2018). Skrining Fitokimia dan Isolasi Senyawa Triterpenoid/Steroid dari Daun Buni (Antidesma Bunius (L.) Spreng.). Talenta Conference Series: Tropical Medicine (TM), 1(1), 271–276.

Lindawati, R, Y., Rona, F., Sudirman, & Andi, N. A. (2023). Pengaruh Air Rebusan Kumis Kucing Terhadap Penurunan Asam Urat Di Desa Manawa Kecamatan Patilanggio. Jurnal Rumpun Ilmu Kesehatan, 3(1), 49–59.

Loranza, B. (2019). Uji Penghambatan Aktivitas Enzim Alfa-glukosidase dan Identifikasi Golongan Senyawa Kimia dari Fraksi Teraktif Daun Buni (Antidesma bunius L.). Skripsi. Fak Matematika Dan Ilmu Pengetahuan. Program Studi Sarjana Farmasi. Depok.

Manopo, C. M., Bodhi, W., & Suoth, E. J. (2020). Uji Aktivitas Antihiperurisemia Kombinasi Ekstrak Etanol Daun Salam (Syzygium polyanthum (Wight.) Walp) dan Tumbuhan

Suruhan (Peperomia pellucida (L.) Kunth) Pada Tikus Putih Jantan (Rattus Norvegicus). Pharmacon, 9(4), 581-588.

Mukhriani, Tahar, N., Rusdi, M., Khaerani, & Almaidah, M. F. (2020). Uji Aktivitas Anti Inflamasi Ekstrak Etanol Daun Buni (Antidesma Bunius L. Spreng) Terhadap Tikus Putih (Rattus Norvegicus). Pakistan Research Journal of Management Sciences, 7(5), 39-44.

Nugraha, Y. ., Sujana, D., & Farida, Y. (2021). Evaluation Of Antihyperuricemic Activity Of Ethanol Extracts Suruhan Herb (Peperomia Pellucida L.), Celery Hetb (Apium graveolens L.) and Extract Combination: Scientific Evidence-Based In Vivo Studies Article History. Jurnal Ilmiah Farmako Bahari, 13(1), 81-89.

Nurhamidah, N., Fadillah, R., Elvinawati, E., & Handayani, D. (2022). Aktivitas Anti Hiperurisemia Ekstrak Akar Kaik-kaik (Uncaria cordata. L. Merr) pada Mencit (Mus muscullus) yang Diinduksi Kalium Oksonat. Jurnal Riset Kimia, 13(2), 152–162.

Rahmadani, D., Manullang, I., Riswan, L. ., Simanjuntak, L. J., Minanda, W., & M. Noer, R. (2024). Pencegahan Gout Arthritis Melalui Diet Rendah Purin & Cinnamon Warm Compresses Di Posyandu Hang Tuah, Kampung Tua Bakau Serip. Media Abdimas, 3(3), 13–17.

Riskesdas. (2018). Laporan Riskesdas 2018 (Kalbar). Lembaga Penerbit Badan Penelitian dan Pengembangan Kesehatan. Jakarta.