UJI AKTIVITAS ANTIPIRETIK EKSTRAK ETANOL UMBUT BATANG ROTAN (Calamus rotang L.) TERHADAP MENCIT PUTIH JANTAN (Mus musculus)
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Abstract
Rattan plant (Calamus rotang L.) is a plant that widely used by the people of Kapuas Hulu, West Kalimantan to treat diseases, as food and craft raw materials. Rattan plants contain flavonoids and alkaloids as secondary metabolites which are thought to have antipyretic activity. The purpose of this study was to determine the antipyretic activity of ethanol extracts of rattan stem umbut induced by 5% peptone. This research uses white mice (Mus musculus) male webster swiss strain as a test animal. The study was conducted using 5 test groups, the negative control group (aquadest), positive control (paracetamol 65 mg / KgBB), ethanol extract of rattan stem extract at a dose of 0.25 g / KgBB; 0.5 g / KgBB and 1 g / KgBB. Mice were induced with 5% peptone solution subcutaneously, then after an increase in rectal temperature ≥ 0.6◦C (fever) mice were treated with oral test solutions. The rectal temperature was measured using a digital thermometer in the 30th, 60th, 90th, 120th, 150th and 180th minutes. The results showed a group of ethanolic extracts of rattan stem at dose 0.25 g / KgBB; 0.5 g / KgBB and 1 g / KgBB had significant differences in the negative control group (p<0.05) with the percentage of antipyretic activity respectively at 117.17%; 154.76% and 226.19%. The conclusion of this research is the ethanol extract group of rattan stem extracts with a dose of 0.25 g / KgBB; 0.5 g / KgBB and 1 g / KgBB have antipyretic activity.
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References
Brunton, L., Lazo, J., dan Parker, K., 2006, Goodman and Gilman’s The Pharmocological basis of Therapeutics, 11th ed, McGraw-Hill, New York.
Guyton, A.C., 1990, Buku Ajar Fisiologi Kedokteran, Edisi 5, Buku Kedokteran EGC, Jakarta.
Hanani, E., 2015, Analisis Fitokimia, Buku Kedokteran EGC, Jakarta.
Ifesinachi, P., 2013, Mechanism of Fever in Humans, Int J Microbiol Immunol Res, Volume 2 (5), 37-43.
Ishida, T., Sato, T., Irifune, M., Tanaka, K., Nakamura, N., Nishikawa, T., 2017, Effect of Acetaminophen, A Cyclooxygenase Inhibitor, On Morris Water Maze Task Performance In Mice, J Psychopharmacol, Volume 21 (7), 757-67.
Kurniati, N. F., Suwandi, D. W., dan Yuniati, S., 2018, Aktivitas Mukolitik Kombinasi Ekstrak Etanol Daun Kemangi dan Ekstrak Etanol Daun Sirih Merah, Pharmaceutical Sciences and Research, Volume 5 (1), 7-13.
Malik, F., Ningsi, A., Bafadal, M., Saktiani, D. N., Wahyuni., 2018, Uji Efek Antipiretik Ekstrak Etanol Buah Wualae (Etlingera elatior (Jack) R.M.Smith) terhadap Mencit Jantan (Mus musculus L.) Galur Balb/C, Jurnal Farmasi, Sains dan Kesehatan, Pharmauho, Volume 4 (1), 9-11.
Naglaa, A. dan Elmaghraby, A.K., 2014, Comparison the Antipyretic Effect of Paracetamol, Metamizole, Sodium and Diclofenac Potassium in Breaking down Fever in Children, J Am Sci, Volume 10 (9), 253-257.
Ningsih, D. dan Rezeki, E.S., 2018, Uji Aktivitas Antipiretik dan Kandungan Flavonoid Total Ekstrak Daun Pepaya, Jurnal Farmasi Indonesia, Volume 2 (15), 101-108.
Ni’ammah, U., dan Arifianto, N., 2018, Perbandingan Efektivitas Kaplet Antipiretik Dua Merek Dagang Parasetamol Dan Produk Generik Terhadap mencit (Mus musculus) Jantan, Journal of Pharmaceutical Science and Medical Research (PHARMED), Volume 1 (2), 22-27.
Ripa, F. A., Dash, P. R. dan Podder, A. K., 2016, Aktivitas Anti-diare dan Hipoglikemik Ekstak Metanol Calamus rotang L pada Tikus, Jurnal Penelitian Farmakognosi, Volume 3 (2), 33-40.
Rivai, H., Nanda, P.E. dan Fadhilah, H., 2014, Pembuatan dan Karakterisasi Ekstrak Kering Daun Sirih Hijau (Piper betle L.), Jurnal Farmasi Higea, Volume 2 (6), 133-144
Sherwood, L., 2001, Fisiologi Manusia: Dari Sel ke Sistem, Buku Kedokteran EGC, Jakarta.
Sherwood, L., 2013, Energy Balanced Temperature Regulation, in Human Physiology : from Cells to Systems, 8th ed, Cengage Learning, Belmont, CA.
Syafitri, N.E., Bintang, M., dan Falah, S., 2014, Kandungan Fitokimia, Total Fenol dan Total Flavonoid Ekstrak Buah Harendong (Melastoma affine D.Don), Current Biochemistry, Volume 1(3), 105-115.
Tawi, G. Y., Maarisit, W., Datu, O. S., dan Lengkey, Y.K., 2019, Uji Efektivitas Ekstrak Etanol Daun Awar-awar Ficus septica Burm F. Sebagai Antipiretik Terhadap Tikus Putih Rattus norvegicus, Jurnal Biofarmasetikal Tropis, Volume 2 (1), 1-9.
Wash, D., 1997, Kapita Selekta Penyakit dan Terapi, Buku Kedokteran EGC, Jakarta.
Zulfa, N. R.A., Sastramihardja, H.S., dan Dewi, M.K., 2017, Uji Efek Antipiretik Ekstrak Air Umbi Bengkuang (Pachyrhizus erosus) pada Mencit (Mus musculus) Model Hiperpireksia, Bandung Meeting on Global Medicine & Health (BaMGMH), Volume 1 (1), 37-41.