ANTIHYPERGLYCEMIC ACTIVITY ETHANOL EXTRACT BARK OF SENGKUANG Dracontomelon dao (Blanco) Merr & Rolfe AGAINST MALE STRAINS (Mus musculus) SWISS WEBSTERS

Article Sidebar

PDF
Published: Jan 28, 2023

Main Article Content

inderiyani inderiyani
a:1:{s:5:"en_US";s:31:"Akademi Farmasi Yarsi Pontianak";}
Sulastri Herdaningsih
Ihsanul Arief Arief

Abstract

Diabetes mellitus (DM) is a serious chronic disease that occurs when the pancreas does not produce enough insulin or when the body cannot effectively use the insulin it produces. Sengkuang Dracontomelon dao (Blanco) Merr & Rofle has the potential as an alternative treatment for DM because it contains secondary metabolites in the form of alkaloids, tannins and flavonoids which have antihyperglycemic properties. This study aims to determine the antihyperglycemic activity of sengkuang stem bark against male white mice. Sengkuang bark is processed into simplicia and then macerated using 96% ethanol as a solvent. Then the extract was used to test antihyperglycemic activity by measuring initial glucose levels with a glucose test strip and given a test solution in the form of 0.5% Na.CMC suspension; glibenclamide 65 mg/kgbb; ethanol extract of sengkuang stem bark dose of 100 mg/kgbb; 200 mg/kgbb and 400 mg/kgbb. Then the test animals were induced with glucose 75 gram/kgbb and blood glucose levels were measured at 0, 30, 60, 90, 120, 150 and 180 minutes. The results showed that the ethanol extract of sengkuang bark at a dose of 400 mg/kgbb had activity as antihyperglycemic indicated by a significant difference with the negative control group.


Keywords : Antihyperglycemia, diabetes mellitus, ethanol extract of sengkuang bark, Dracontomelon dao (Blanco) Merr & Rofle

Article Details

How to Cite
inderiyani, inderiyani, Herdaningsih, S. ., & Arief , I. A. . . . (2023). ANTIHYPERGLYCEMIC ACTIVITY ETHANOL EXTRACT BARK OF SENGKUANG Dracontomelon dao (Blanco) Merr & Rolfe AGAINST MALE STRAINS (Mus musculus) SWISS WEBSTERS. Jurnal Komunitas Farmasi Nasional, 2(2). Retrieved from https://jkfn.akfaryarsiptk.ac.id/index.php/jkfn/article/view/59
Issue
Vol. 2 No. 2 (2022): Jurnal Komunitas Farmasi Nasional
Section
Articles
Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

 

References

Aloisia, M., 2017, Ekstraksi dan Real Kromatografi, Deepublish, Yogyakarta.

American Pharmacists Association (AphA), 2012, Drug Information Handbook ed 21st, Lexi Comp Inc, USA

Depkes RI, 1979, Farmakope Indonesia, Edisi III, Departemen Kesehatan Republik Indonesia, Jakarta.

Depkes RI, 1985, Cara Pembuatan Simplisia, Departemen Kesehatan RI, Jakarta.

Depkes RI, 1986, Sediaan Galenik, Departemen Kesehatan Republik Indonesia, Jakarta.

Depkes RI, 1995, Farmakope Indonesia, Edisi IV, Departemen Kesehatan Republik Indonesia, Jakarta.

Depkes RI, 2000, Acuan Sediaan Herbal, Departemen Kesehatan Republik Indonesia, Jakarta.

Depkes RI, 2000, Parameter Standar Umum Ekstrak Tumbuhan Obat, Departemen Kesehatan Republik Indonesia, Jakarta.

Dipiro, Joseph T., 2008, Pharmacotherapy A Patophysiological Approach 7th edition. The McGraw Hill Companies. USA.

Falah, F., Sayektiningsih, T., dan Noorcahyati, N., 2013, Keragaman Jenis dan Pemanfaatan Tumbuhan Berkhasiat Obat Oleh Masyarakat Sekitar Hutan Lindung Gunung Beratus, Kalimantan Timur, Jurnal Penelitian Hutan dan Konservasi Alam, Vol 10 (1): 1-18.

Ganiswara, S., 2007, Obat Otonom dalam Farmakologi dan Terapi ed.5, Departemen Farmakologi dan Terapeutik Fakultas Kedokteran Universitas Sumatera Utara.

Hanani, E., 2015, Analisis Fitokimia. Buku Kedokteran EGC, Jakarta.

Handayani, S.R., (2019), Uji Aktivitas Antidiabetes Infusa Daun Kemuning (Murraya Paniculata L Jack.) Pada Mencit Putih Jantan Yang Diinduksi Glukosa. Indonesian Journal On Medical Science, Vol 6(1).

Harborne, J.B., 1984, Metode Fitokimia: Penuntun cara Modern Menganalisis Tumbuhan, Institut Teknologi Bandung, Bandung.

Harborne, J.B., 1987, Metode Fitokimia: Penuntun cara Modern Menganalisis Tumbuhan, Institut Teknologi Bandung, Bandung.

Heyne, K., 1987, Tumbuhan Berguna Indonesia (terjemahan) Jilid III, Badan Penelitian dan Pengembangan Kehutanan, Yayasan Sarana Wana, Jakarta

Kemenkes RI, 2011, Profil Kesehatan Indonesia, Kementrian Kesehatan Republik Indonesia, Jakarta.

Kemenkes RI, 2018, Riset Kesehatan Dasar, Badan Penelitian dan Pengembangan Kesehatan, Kementrian Kesehatan Republik Indonesia, Jakarta.

Khan, M.R., dan A.D. Omoloso, 2002, Antibacterial and Antifungan Activities of Dracontomelon dao, Elsivier, Fitoterapia 73 (2002).

Kurniati, N. F., Suwandi, D. W., dan Yuniati, S., 2018, Aktivitas Mukolitik Kombinasi Ekstrak Etanol Daun Kemangi dan Ekstrak Etanol Daun Sirih Merah, Pharmaceutical Sciences and Research, 5(1): 7-13.

Kurniawan, D., Yuliawati, R., Habibi, M., dan Ramlan, E.E., 2020, Efektivitas Ekstrak Etanol Daun Sengkuang (Dracontomelon dao) sebagai Larvasida Alami, Jurnal Penelitian Ekosistem Dipterokarpa, 5(2): 79-86.

Lemmens, R.H.M.J., Soerianegara, I dan Wong, W.C., (Eds.), 1995, Timber Trees: Minor Commercial Timbers Plant Resources of South-East Asia No 5 (2), PROSEA, Backhuys Publishers, Leiden.

Medero, A.J.D.L., 2008, During the Mouse Lecture and Wet Lab, Terdapat di : www.uprh.edu/rise/activities/mouse/mouse.htm. (Diakses 27 Maret 2020).

Mycek, Mary J., Richard A. Harvey, dan Pamela C. Champer., 2001, Farmakologi Ulasan Bergambar. Edisi 2nd. Alih Bahasa: Azwar Agoues, Widya Medika, Jakarta.

Mutschler, E., 2010, Dinamika Obat, Penerjemah: Mathilda B dan Anna S., Edisi kelima, Institut Teknologi Bandung, Bandung.

Noorcahyati, 2012, Tumbuhan Berkhasiat Obat Etnis Asli Kalimantan, Balai Penelitian Teknologi Konservasi Sumber Daya Alam, Badan Litbang Kementrian Kehutanan, Balikpapan.

Priyambodo, 2003, Pengendalian Hama Tikus Terpadu, Penebar Swadaya, Jakarta.

Setijono, M.M., 1985, Mencit (Mus musculus) Sebagai Hewan Percobaan. Skripsi. Institut Pertanian Bogor, Bogor.

Smith, B.J.B. dan S. Mangkoewidjojo, 1998, Pemeliharaan Pembiakan dan Penggunaan Hewan Percobaan di Daerah Tropis, Universitas Indonesia, Jakarta.

Sonia, R., yusnelti, dan Fitrianingsih., 2019, Efektivitas Ekstrak Etanol daun Durian (Durio zibethinus (Linn.)) sebagai Antihiperurisemia, Jurnal Kefarmasian Indonesia, 10(2): 130-139.

Syafitri, A. dan Mardatillah, H.F., 2022, Uji Efektivitas Antidiabetes Kombinasi Ekstrak Buah Pare (Momordica charantia L.) dan Kelopak Bunga Rosella (Hibiscus sabdariffa L.) pada Tikus Jantan sebagai Hewan Percobaan, Jurnal Farmasi dan Herbal, Vol 4(2): 1-8.

Syafitri, N.E., Bintang, M., dan Falah, S., 2014, Kandungan Fitokimia, Total Fenol dan Total Flavonoid Ekstrak Buah Harendong (Melastoma affine D.Don), Current Biochemistry, 1(3): 105-115.

Tan HT dan Kirana R., 2002, Obat-obat Penting : Khasiat, Penggunaan dan Efek- efek Sampingnya, PT. Gramedia, Jakarta.

Tjay, TH. dan Rahardja K., 2013, Obat-obat Penting : Khasiat, Penggunaan dan Efek- efek Sampingnya, PT. Elex Media Komputindo, Jakarta.