SINERGI FITOKIMIA DAUN KELOR (Moringa oleifera Lam) DAN JAHE MERAH (Zingiber officinale var. rubrum) SEBAGAI ANTIINFLAMASI ALAMI PADA MENCIT JANTAN (Mus musculus) SINERGI FITOKIMIA DAUN KELOR (Moringa oleifera Lam) DAN JAHE MERAH (Zingiber officinale var. rubrum) SEBAGAI ANTIINFLAMASI ALAMI PADA MENCIT JANTAN (Mus musculus)

Abstract

Moringa leaves contain the compound quercetin which is known as a strong antioxidant and is able to inhibit the COX-2 enzyme, while red ginger contains gingerol, which has anti-inflammatory properties through inhibiting cyclooxygenase-2 (COX-2) and pro-inflammatory cytokines. This study aims to evaluate whether the combination of Moringa leaf extract and red ginger provides a synergistic effect as an anti-inflammatory and to determine the most effective dose of this combination, considering its potential as a herbal medicine with anti-inflammatory properties.

This research uses a testing method by inducing edema on the soles of mice's feet using carrageenan. The edema volume was then measured with a plethysmometer to assess the effectiveness of the extract combination.

The results showed that the combination of Moringa leaf extract and red ginger provided a significant anti-inflammatory effect, especially at a combined dose of 35 mg/KgBW of moringa and 100 mg/KgBW of red ginger, with edema inhibition reaching 92.25% at time 6. However, increasing the dose of red ginger (200 mg/KgBW) produced a lower effect. This research indicates a synergistic effect from the combination of the two extracts in reducing inflammation, but dosage variations must be considered to obtain optimal effectiveness.