Jurnal Komunitas Farmasi Nasional

Determination of Total Phenolic Content, Test of Sunscreen and Antibacterial Activity of Propionibacterium acnes from Ethanol Extract of Gambir Leaves (Uncaria gambir Roxb)

shoraya anis wulandari Sumarsono — 2024-07-08

Gambir leaves (Uncaria gambir Roxb) contain phenolic compounds that have the potential to act as sunscreen and have antibacterial activity. This study aims to determine the total phenolic content, SPF value of gambier leaf extract in vitro and antibacterial activity against Propionibacterium acnes. Gambier leaf extract was made using the maceration method with 96% ethanol solvent. Total phenolic content and sunscreen activity were tested by measuring absorption using UV-Vis spectrophotometry, while the antibacterial activity test used the agar well method. Data were analyzed using Microsoft Excel to test phenolic levels and SPF values, while for antibacterial activity using SPSS 25 with the One Way Anova test. The results showed that the total phenolic content of gambier leaf extract was 1.3322 mgGAE/g ± 0.2456 with ultra-protective SPF values at concentrations of 120, 100 and 80 ppm respectively, namely 31,94; 22,62; and 15,24. Gambir leaf extract has antibacterial activity against Propionibacterium acnes with inhibitory diameters at concentrations of 50, 25 and 12.5% respectively, namely 23,67; 18,00; and 14,57 mm.

ANALYSIS MANAGEMENT OF DAMAGED DRUGS, EXPIRED DRUG AND DEAD STOCK IN PUBLIC HEALTH CENTER IN PONTIANAK CITY

heny puspasari — 2024-07-08

Inefficient drug management can lead to budget overlap and inappropriate drug use. This results in a reduced availability of drugs, drugs accumulate due to inappropriate drug planning, and drug costs become expensive due to irrational use of drugs. Based on this, it shows that the percentage of damaged drugs, expired drugs, and dead stock drugs relatively high, so further research is needed on drug management. This study aims to describe and analyze the percentage of damaging drugs, expired drugs, and dead stock drugs in the UPTD of the Pontianak City Health Center. This study is a descriptive analysis with retrospective data collection by observing and evaluating data on damaged drugs, expired drugs, and dead stock drugs in 2020. The results showed no defective drugs were found in UPTD Puskesmas S and B, expired drugs in UPTD Puskesmas S and B. 15.4% and 16.7%, and dead stock in UPTD B was 3.3% and there was no dead stock in UPTD Puskesmas S. this study concluded that the percentage of damaged drugs was following the research indicators, namely 0%, the percentage Expired drugs and dead stock drugs are not following the research indicators, namely 0%, this is caused by several factors including changes in prescribing patterns and expiration dates that are too close, so it is necessary to evaluate drug planning according to to needs and improve management of expired drug management and stock is dead.

ANTIOXIDANT ACTIVITY TEST OF LOTION ETANOL EXTRACT OF PISANG KEPOK FLOWERS (Musa acuminata x M. balbisiana) USING DPPH (1,1-diphenyl-2-picryilhydrazyl) METHODS

Husnani Husnani — 2024-07-08

Kepok banana flower (Musa acuminate x M. balbisiana) is known to contain flavonoid, polyvenol and saponin compounds that function as antioxidants. The purpose of this study was to determine the antioxidant activity and to determine the IC50 value of lotion of kepok banana flower (Musa acuminate x M. balbisiana) as an antioxidant. Antioxidant activity testing of lotion of kepok banana flower (Musa acuminate x M. balbisiana). Ethanol extract of pisang bunga kapok was obtained by extraction using maceration method with 96% ethanol for 3x24 hours. Then the extract was formulated into lotion preparations with variations of banana flower extract, namely 0.4%, 0.6%, and 0.8%. The results of the preparation of pisang kepok flower (Musa acuminate x M. balbisiana) with various concentrations of extracts meet the requirements of a good lotion preparation. Furthermore, it was tested using the DPPH (1,1-diphenyl-2-picryilhydrazyl) method with vitamin C comparator measured at a wavelength of 516.20 nm. The results of the lotion test of ethanol extract of kepok banana flower have antioxidant activity with IC50 values at FI 0.4% (33.83µg/ml), FII 0.6% (27.85µg/ml), FIII 0.8% (10.04µg/ml). Based on the IC50 data, it can be seen that FIII with a concentration of 0.8% has a very strong antioxidant value compared to FI and FII lotions.

Translated with DeepL.com (free version)

Protection of Pacing Rhizome Extract Against Insulin Resistance in Animal Models Induced by High Fat Diet and Fructose

Aulia Nurfazri Istiqomah Aulia Nurfazri Istiqomah — 2024-07-08

Insulin resistance is a condition where the sensitivity of cells or tissues to insulin decreases, which is one of the main factors causing type 2 diabetes mellitus. Current diabetes therapy is still limited to synthetic drugs which can cause side effects, so alternative diabetes therapy is being sought. using natural materials, one of which is using pacing. The pacing rhizome plant contains the compound diosgenin which has antidiabetic properties.

This study aims to determine the activity of ethanol extract of pacing rhizomes in increasing insulin sensitivity and the effective dose in increasing insulin sensitivity.

Testing was carried out preventively using an animal model of insulin resistance induced by high fat and fructose feed orally for 42 days. The test animals were divided into six groups, namely normal, induction, comparison metformin 45 mg/KgBW, ethanol extract of rhizome pacing (EERP) dose 150 mg/KgBW, 300 mg/KgBW and 450 mg/KgBW. The parameters measured were blood glucose levels and insulin tolerance test constants.

From the research results, it was found that ethanol extract of pacing rhizome at a dose of 300 mg/KgBW could increase insulin sensitivity.

Keywords: insulin resistance, pacing, blood glucose levels, Costus speciosus

KORELASI KARAKTERISTIK DENGAN KEPATUHAN MINUM OBAT PASIEN DIABETES MELLITUS TIPE 2 DI PUSKESMAS S.PARMAN BANJARMASIN

yugo susanto — 2024-07-08

Diabetes Mellitus (DM) merupakan penyakit metabolik kronis dengan
karakteristik hiperglikemia. Pengobatan membutuhkan waktu lama, kepatuhan
minum obat menjadi faktor yang sangat penting. Belum banyak penelitian yang
menguji hubungan antara tingkat kepatuhan minum obat pasien diabetes mellitus
tipe 2 dengan karakteristik pasien. Tujuan penelitian ini untuk mengetahui
gambaran karakteristik, kepatuhan minum obat, dan menguji hubungan antara
karteristik dengan tingkat kepatuhan minum obat pasien diabetes mellitus tipe 2 di
Puskesmas S. Parman Banjarmasin.
Penelitian ini adalah penelitian observasional dengan pendekatan cross
sectional. Sampling dilakukan dengan consecutive sampling. Pengambilan sampel
sampai periode penelitian yang telah ditetapkan. Didapat sejumlah 76 pasien.
Karakteristik pasien diolah dengan statistik deskriptif..Kepatuhan minum obat
diukur dengan metode pill count. Hubungan antar variabel diuji dengan spearman
test.
Hasil penelitian menunjukkan karekteristik pasien yang dominan adalah jenis
kelamin perempuan 51 (67,1%), usia 46-55 tahun 40 (52,6%), pendidikan SMA 34
(44,7%), pekerjaan ibu rumah tangga 33 (43,4%), lama menderita >5 tahun 28
(36,8%), jumlah obat 1 jenis obat 51 (67,1%), dan tanpa komorbid 41 (53,9%).
Kepatuhan minum patuh 54 (71,1%) dan tidak patuh 22 (28,9%). Adanya hubungan
yang signifikan antara karakteristik jenis kelamin (p=0,022) dan usia pasien
(p=0,025) dengan kepatuhan minum obat.
Kesimpulan Karakteristik jenis kelamin dan usia pasien memiliki hubungan
terhadap kepatuhan minum obat pasien diabetes melitus tipe 2 di Puskesmas S.
Parman Banjarmasin

GAMBARAN POLA PENGGUNAAN ANTIBIOTIKA PADA PASIEN PNEUMONIA DI PUSKESMAS S PERIODE JANUARI – DESEMBER 2023

sri rahayu — 2024-07-08

Pneumonia is an inflammation of the lungs which causes pain when breathing and limited oxygen intake. There are various ways in which pneumonia can be spread, including coughing and sneezing. According to data from Risksdas, there has been an increase in the prevalence of pneumonia at all ages from 2.1% in 2007 to 2.7% in 2013 and 4.5% in 2018. Antibiotics are in 6th place, including the 10th most commonly used drugs in Puskesmas S in 2022. This research aims to gain insight into the pattern of antibiotic use in pneumonia patients at the S Community Health Center for the period January-December 2023. This research is a descriptive study that retrospectively analyzes data using a purposive sampling technique to obtain a sample of 232 prescriptions. The results indicated that amoxicillin was the most commonly prescribed antibiotic, with 186 prescriptions (80.17% of the total). Cefixime was the second most commonly prescribed antibiotic, with 24 prescriptions (10.34% of the total). Cefadroxil was the third most commonly prescribed antibiotic, with 22 prescriptions (9.49% of the total). It is worth noting that pneumonia attacks children aged 0-5 years as many as 98 patients with a percentage of (42.24%), and adults aged 46-55 years with a percentage of 14 patients with a percentage of (6.04%). It would also be beneficial to consider the gender of the patients, with males being more susceptible than females. It is worth noting that men were more likely to suffer from pneumonia, with 134 patients (57.76%) affected. The drug class that was most widely used was the penicillin drug group, with 186 prescriptions (80.18%).

GAMBARAN TINGKAT KEPUASAN PASIEN TERHADAP PELAYANAN KEFARMASIAN DI APOTEK MELIA BANJARMASIN

Raudatul Patimah — 2024-07-08

Kepuasan pasien dapat dikatakan sebagai tolak ukur untuk mengetahui
kualitas pelayanan yang diberikan oleh apotek. Jika kepuasan pasien yang
dihasilkan baik, berarti pelayanan yang disuguhkan oleh apotek tersebut juga baik.
Penelitian ini bertujuan untuk mengetahui tingkat kepuasan pasien terhadap
pelayanan kefarmasian di Apotek Melia Banjarmasin yang meliputi ketanggapan,
kehandalan, jaminan, keramahan dan bukti nyata. Penelitian ini merupakan jenis
penelitin deskriptif dengan pendekatan kuantitatif. Teknik pengambilan sampel
menggunakan non-probability sampling dengan metode accidental sampling. Hasil
penelitian terhadap 100 responden mengenai tingkat kepuasan pasien di Apotek
Melia Banjarmasin menunjukkan bahwa kategori tingkat kepuasan dari yang
terbesar secara berurutan yaitu pada dimensi keramahan kategori sangat puas
(3,38), jaminan kategori sangat puas (3,31), ketanggapan kategori puas (3,25),
kehandalan kategori puas (3,16), dan bukti nyata kategori puas (3,15). Berdasarkan
data tersebut, dapat disimpulkan bahwa tingkat kepuasan pasien terhadap pelayanan
kefarmasian di Apotek Melia Banjarmasin berdasarkan lima dimensi kualitas
pelayanan adalah puas dengan nilai 3,25.
Kata Kunci: Apotek, Pelayanan Kefarmasian, Kepuasan Pasien

Antibacterial Antibacterial Activity of 96% Ethanol Extract in Old Leaves of Medang Pirawas (Litsea elliptica Blume) to Staphylococcus aureus Bacteria

MARATU SOLEHA — 2024-07-08

Litsea elliptica Blume, is one type of traditional medicinal plant that is widely used by the Indonesian people. This symplisia can be used to treat headaches, fever, stomach ulcers, and also as an insect repellent. Litsea elliptica Blume also has antimicrobial and antioxidant properties. Objective: This study aims to determine whether 96% ethanol extract of Litsea elliptica Blume leaves has antibacterial activity against Staphylococcus aureus bacteria. Methods: This research is a laboratory experiment with descriptive quantitative method conducted in this study to test the antibacterial properties of 96% ethanol extract of Medang Pirawas (Litsea elliptica Blume) against Staphylococcus aureus bacteria. Results: The yield of the thick extract of Litsea elliptica Blume was 19.36 %, and the classes of secondary metabolite compounds found were phenols, flavonoids, saponins, tannins, alkaloids, and terpenoids. The results of the antibacterial activity test of the viscous extract of Litsea elliptica Blume did not show antimicrobial properties against the growth of Staphylococcus aureus, which was characterized by not forming a clear zone on the media. Conclusion: From these results it can be concluded that there is no antibacterial activity of ethanol extract of medang pirawas (Litsea elliptica Blume) leaves against the growth of Staphylococcus aureus bacteria.

DETERMINATION OF SUN PROTECTION FACTOR (SPF) VALUE OF ETHANOLIC EXTRACT OF URENA LOBATA L. FLOWERS

Athiah Masykuroh — 2024-07-08

Urena lobata L. are known contains secondary metabolites of alkaloids, terpenoids, phenols, flavonoids, saponins and tannins and have very strong antioxidant activity. This causes the ethanolic extract of Urena lobata L. flowers have the ability to ward off free radicals and UV radiation. This research aims was to find out whether the ethanolic extract of urena lobata L. flowers has Sun Protection Factor (SPF) activity and how much value it has. Determination of the SPF value was carried out by measuring the absorbance of the ethanolic extract of Urena lobata L. flowers with concentration of 4000 ppm using UV-Vis Spectrophotometry at 290-320 nm wavelength. The results showed that the ethanolic extract of Urena lobata L. flowers has SPF activity. The average SPF value obtained was 2.43, which is included in the weak category.

FORMULASI MOUTHWASH EKSTRAK ETANOL DAUN KESUM (Polygonum minus Huds.)

Dian Kartikasari — 2024-07-08

Kesum leaves (Polygonum minus Huds.) contain phenolic compounds, flavonoids, alkaloids, steroids, terpenoids, tannins, saponins and essential oils. This study aims to determine the quality of Mouthwash preparations from ethanol extract of kesum leaves (Polygonum minus Huds.) Ethanol extract of kesum leaves (Polygonum minus Huds.) obtained by extraction using maceration method with 70% ethanol solvent for 3x24 hours. Furthermore, the extract was formulated into mouthwash preparations with variations in the concentration of ethanol extract of kesum leaves, namely 0.5%, 1%, 1.5%. Quality evaluation of the moutwash preparation includes organoleptic, pH, specific gravity and viscosity. The results obtained are in the organoleptical test results in the form of a liquid, smelling a distinctive aroma of kesum leaves and menthol, 0.5% formulation R1 and R2 are brownish yellow, R3 is light yellow and in 1% formulation R1, R2, R3 are brownish yellow and in 1.5% formulation R1, R2 and R3 are solid yellow, sweet taste, slightly spicy and slightly bitter in formulas 0.5%, 1% and 1.5% in R1, R2 and R3. Clarity test on formulations 0.5%, 1%, 1.5% produced clear preparations. Viscosity test in the 0.5% formula is (2.33 ± 0.577) cPs, 1% and 1.5% formulas are (2 ± 1 cPs). Specific gravity test in the 0.5% formula is (0.86 ± 0.33), 1% formula is (1.02 ± 0.01), 1.5% (1.05 ± 0.02). The pH test in the 0.5% formula is (6.28 ± 0.20), 1% formula is (5.46 ± 0.27), 1.5% formula is (5.18 ± 0.03). So it can be concluded that the three formulas have.