Jurnal Komunitas Farmasi Nasional

KAJIAN AKTIVITAS FARMAKOLOGI DAN MEKANISME AKSI POLIHERBAL EKSTRAK PEGAGAN, MENIRAN, DAN KENCUR: LITERATURE REVIEW

Rahmat Santoso Santoso — 2025-02-03

Plants, as natural sources of food, herbs, and medicines, have been used for thousands of years in many traditional
healing systems. In both developed and developing countries, the use of herbal plants to treat various diseases and
the research into products with their properties have increased rapidly. Although there is already a vast amount of
literature, aspects such as phytochemistry, pharmacological activity, and mechanisms have not been reviewed
comprehensively. This review article aims to provide a collection of information about selected herbal plants, namely
Meniran (Phyllanthus niruri Linn.), Gotu Kola (Centella asiatica (L.) Urban), and Kencur (Kaempferia galanga L.).
In compiling this review article, the literature study method from collections of national and international journals
was used. Based on the resulting literature survey, it can be concluded that there are still few journals that discuss
aspects of these plants, especially the mechanisms of action.
Keywords: Phyllanthus niruri, Centella asiatica, Kaempferia galanga, Pharmacological activity, Mechanisms of
action, and Phytochemistry.

LITERATURE STUDY OF THE EFFECTIVENESS OF ADMINISTRATION OF MEDICINAL PLANTS IN HEALING PERINEAL WOUNDS IN POSTPARTUM MOTHER

Fuzi Fauziah — 2025-02-03

Aim: This study aims to determine which medicinal plants and plant parts are most effective in healing perineal wounds in postpartum women and to find out information regarding the secondary metabolite content in plants which have activity in treating perineal wounds. Method: This research uses a literature study method by conducting journal searches using the Harzing's Publish or Perish application which is connected to database sources such as Google Scholar, PubMed, and Science Direct. Journal searches used the keywords "luka perineum", "tanaman obat", "perineal wound", and "medicinal plants". Journal selection was carried out based on inclusion and exclusion criteria. Results: The results of the study showed that there were 13 journals that met the inclusion criteria, and it was found that 12 plants were effective in healing perineal wounds including silymarin, aloe vera, rosemary, torbangun, red betel, green betel, st. John's wort, sidaguri, black cumin, turmeric, common mullein and green tea. Conclusion: The most effective plant in healing perineal wounds is the Silymarin plant (Silybum marianum). The most widely used part of the plant is the leaves. Secondary metabolite compounds contained in almost all plants are flavonoids.

DETEKSI SENYAWA PIPERINE DARI CABE JAWA (Piper retrofractum Vahl) UNTUK TERAPI ANTI HIPERKOLESTEROLEMIA STUDI In Silico

Umarudin Umarudin — 2025-02-03

Increased cholesterol levels in the blood characterize Hypercholesterolemia due to excessive fat consumption, leading to an imbalance between fat intake and metabolism. The plant Piper retrofractum Vahl, commonly known as Javanese long pepper, is recognized for its various benefits and properties, including its use in traditional medicine formulations and as a functional food ingredient. The secondary metabolite present in Javanese long pepper is piperine, which imparts a characteristic intense flavor and has been shown to have the potential to lower Hypercholesterolemia, necessitating an in silico study. This research aims to detect the piperine compound from Piper retrofractum Vahl as an anti-hypercholesterolemia therapy through an in silico study. The methodology involves the preparation of compounds using the Pyrx 0.8 application in PDB format, followed by preparing the HMG-CoA Reductase protein using Discovery Studio to remove ligands and water molecules. Molecular docking was conducted using an in silico approach with HEX Cuda 8.0.0 software. The results of the in silico study indicate that piperine from Javanese long pepper interacts with HMG-CoA Reductase, demonstrating a binding affinity value of -317.90 and interacting with three amino acid residues. These findings suggest that Javanese long pepper can be used as an anti-hypercholesterolemia therapy.

ANTIOXIDANT ACTIVITY TESTING OF ETHANOL FRACTION, ETHYL ACETATE FRACTION, N-HEXANE FRACTION OF NIPAH LEAVES (Nypa fruticans Wurmb.)

Husnani Husnani — 2025-02-03

Free radicals are ultraviolet rays that cause damage to the skin. Therefore, antioxidants are needed to prevent the dangers of free radicals in the body while repairing damaged body cells. One of the plants that contain compounds that have potential as antioxidants is nipah leaves. Previous research states that Nipah leaves have antioxidant activity with an IC50 value of 9.662 ppm with a very strong category, so this study aims to determine the antioxidant activity of the ethanol fraction, ethyl acetate fraction and n-hexane fraction, and determine which fraction can provide the strongest antioxidant activity value. The methods used in this study include preparation of simplisia, preparation of nipah leaf fractions, phytochemical screening of fractions, antioxidant activity test of nipah leaf fractions using DPPH method.

SINERGI FITOKIMIA DAUN KELOR (Moringa oleifera Lam) DAN JAHE MERAH (Zingiber officinale var. rubrum) SEBAGAI ANTIINFLAMASI ALAMI PADA MENCIT JANTAN (Mus musculus)

Nurwani Purnama Aji Nurwani — 2025-02-03

Moringa leaves contain the compound quercetin which is known as a strong antioxidant and is able to inhibit the COX-2 enzyme, while red ginger contains gingerol, which has anti-inflammatory properties through inhibiting cyclooxygenase-2 (COX-2) and pro-inflammatory cytokines. This study aims to evaluate whether the combination of Moringa leaf extract and red ginger provides a synergistic effect as an anti-inflammatory and to determine the most effective dose of this combination, considering its potential as a herbal medicine with anti-inflammatory properties.

This research uses a testing method by inducing edema on the soles of mice's feet using carrageenan. The edema volume was then measured with a plethysmometer to assess the effectiveness of the extract combination.

The results showed that the combination of Moringa leaf extract and red ginger provided a significant anti-inflammatory effect, especially at a combined dose of 35 mg/KgBW of moringa and 100 mg/KgBW of red ginger, with edema inhibition reaching 92.25% at time 6. However, increasing the dose of red ginger (200 mg/KgBW) produced a lower effect. This research indicates a synergistic effect from the combination of the two extracts in reducing inflammation, but dosage variations must be considered to obtain optimal effectiveness.

TESTING THE ANALGETIC ACTIVITY OF ETHANOL EXTRACT OF MICE TRUMBO LEAVES (Typhonium flagelliiforme Lodd.) ON MALE WHITE MICE (Mus musculus L.) INDUCED BY 1% ACETIC ACID

Sulastri Herdaningsih — 2025-02-03

Pain is an unpleasant sensory and psychological feeling and is associated with tissue damage. With the chemical stimulation method, pain is an unpleasant sensory and emotional feeling associated with tissue damage. This study aims to determine the analgesic activity of ethanol extract of rat taro leaves (Typhonium flagelliforme Lodd.) on male white mice (Mus musculus L.) induced by 1% acetic acid and at what dose of ethanol extract of rat taro leaves (Typhonium flagelliforme Lodd.) has analgesic activity. The percentage results of the ethanol extract of rat taro leaves (Typhonium flagelliforme Lodd.) have analgesic activity which can be seen from the percentage results of Mefenamic Acid of (89.91%) and the ethanol extract of rat taro leaves (Typhonium flagelliforme Lodd.) with a dose of 100 mg/kgBW, 200 mg/kgBB, and 300 mg/kgBB respectively amounted to (52.13%, 60.34 % and 86.58 %). The percentage results of the positive control, extracts 1, 2, and 3 have a significant difference to the negative control of 0.000 (p<0.05).

Keywords: Analgesic, ethanol extract of rat taro leaves (Typhonium flagelliforme Lodd.) Male white mice (Mus musculus L.)

PROFILE OF RATIONAL DRUG USE AT XY HEALTH CENTER IN 2023

sri rahayu — 2025-02-03

Rational Drug Use (RDU) is a health service that strives to ensure the safety, effectiveness and cost-effectiveness of therapy in the community. We believe that the success of POR at the Community Health Centre can be measured by the percentage of antibiotic use (AB) for non-pneumonia, which has been reduced to 20%, the percentage of antibiotics in non-specific diarrhoea, which has been reduced to 8%, the percentage of injections in myalgia, which has been reduced to 1%, and the average number of drug items per prescription, which has been reduced to 2.6 items. The objective of this study was to gain a better understanding of the profile of rational drug use at the XY Community Health Centre in 2023. This research is a type of descriptive study, with data collection based on data contained in patient prescriptions. The data collection technique used was purposive sampling, which yielded a sample of 201. The results indicated that the percentage of antibiotic use in ISPA non-pneumonia cases in January was 17.64%, in February 50%, in March 36.84%, in April 25%, in May 28.12%, in June 19.04%, in July 21.15%, in August 43.63%, In September, the percentage of antibiotic use was 13.43%, in October it was 34.78%, in November it was 38.29%, in December it was 28.84%, and while the percentage of antibiotic use in non-specific diarrhoea in January was 0%, in February it was 5.88%, in March it was 7.69%, in April it was 0%, in May it was 0%, in June it was 10.63%. .63%), July (0%), August (11.76%), September (3.84%), October (36%), November (8.69%), December (0%), The average percentage of antibiotic use in ISPA non-pneumonia was 29.73%, while for non-specific diarrhoea was 7.04%. It can be surmised that, with regard to the profile of rational drug use for ISPA non-pneumonia at the XY Community Health Centre, the monthly average still falls short of WHO standards. Conversely, the profile of rational drug use for non-specific diarrhoea for the monthly average has met WHO standards.

BIOAKTIVITAS SEDIAAN GEL NANOKOLOID PERAK HASIL BIOSINTESIS MENGGUNAKAN EKSTRAK TANAMAN KELADI SARAWAK (Alocasia macrorrhizos (L.)) TERHADAP BAKTERI Escherichia coli

Athiah Masykuroh — 2025-02-03

Biological activity (bioactivity) test of silver nanocolloid gel biosynthesized by Alocasia macrorrhizos (L.) plant extract and AgNO₃ solutions against Escherichia coli bacteria has been conducted. The gel preparation was made with silver nanocolloids as an active ingredient. The AgNO₃ solution used at biosynthesis process was made in 3 concentration variations : 0.05 (F1); 0.10 (F2) and 0.15 M (F3). Antibacterial activity test was conducted by paper disc diffusion method. The measuring results was diameter of the clear zone formed around the paper disc : 11.90 mm (F1), 12.67 mm (F2) and 13.13 mm (F3) with a positive control of neomycin sulfate gel of 23.16 mm. Based on these results, it can be concluded that the silver nanocolloid gel has inhibitory power against Escherichia coli bacteria with strong category for all variations.