Jurnal Komunitas Farmasi Nasional

FORMULASI SEDIAAN KRIM EKSTRAK BIJI TELANG MUDA SEGAR (CLITORIA TERNATEA L.) DAN UJI PENETAPAN KADAR VITAMIN C

2026-02-13T04:01:10+00:00

Paparan sinar matahari menjadi penyebab kerusakan kulit sehingga membutuhkan
sediaan krim yang mengandung antioksidan. Antioksidan merupakan senyawa yang dapat
mencegah terjadinya kerusakan akibat oksidasi, hal ini ditentukan pada biji telang muda
segar (Clitoria ternatea L.) yang mana mengandung vitamin C. Penelitian ini
memformulasikan ekstrak biji telang muda segar (Clitoria ternatea L.) menjadi sediaan
krim dengan perbedaan konsentrasi 4%, 6% dan 8%. Penelitian dilakukan uji evaluasi
sifat fisik (organoleptis, homogenitas, viskositas, uji daya sebar, uji daya lekat, dan uji
tipe emulsi), (pH) dan uji penetapan kadar vitamin C dengan metode spektrofotometri.
Hasil pengujian ini menunjukkan bahwa uji sifat fisik (organoleptis, homogenitas,
viskositas, uji daya sebar, uji daya lekat, dan uji tipe emulsi) telah memenuhi syarat, uji
(pH) menunjukkan hasil nilai pH pada rentang 5,5 - 6,5 (memenuhi syarat) dan Hasil
penetapan kadar vitamin C tertinggi yaitu F3 sebesar 54,41%.
Kata Kunci: Ekstrak Biji Telang Muda, Krim, Penetapan Kadar Vitamin C

HUBUNGAN RASIONALITAS PENGGUNAAN OBAT TERHADAP OUTCOME KLINIS PADA PASIEN DEMAM BERDARAH DENGUE (DBD) DI RSUD Dr. M. YUNUS BENGKULU JANUARI-OKTOBER 2024

2026-02-13T04:06:30+00:00

Kasus yang terjadi karena adanya virus dengue dan disebabkan melalui gigitan nyamuk aedes aegypti merupakan salah satu penyakit menular yang disebut Demam Berdarah Dengue (DBD). Kasus ini di Indonesia terjadi peningkatan pada tahun 2024. Diberikan pengobatan suportif dan simptomatik yang tepat dapat mempengaruhi keberhasilan pengobatan pada pasien. Tujuannya mengetahui antara hubungan rasionalitas penggunaan obat antipiretik-analgesik dan terapi cairan terhadap outcome klinis suhu badan dan jumlah trombosit pasien rawat inap di RSUD Dr. M. Yunus Bengkulu. Penelitian ini menggunakan metode analitik observasional mendekati cross sectional dan diambil datanya secara retrospektif. Sampel yang diteliti sebanyak 100 pasien selama periode Januari-Oktober 2024. Rasionalitas penggunaan obat pada penelitian ini mendapatkan hasil tepat diagnosis 99%, tepat indikasi 100%, tepat pemilihan obat antipiretik-analgesik 92% dan terapi cairan 100%, tepat dosis antipiretik-analgesik 95% dan terapi cairan 85%, tepat lama pemberian obat 99%, tepat cara pemberian, tepat interval waktu pemberian, tepat pasien, dan tepat informasi sebanyak 100%. Analisis rasionalitas penggunaan obat antipiretik-analgesik terhadap suhu badan dengan uji chi-Square mendapatkan hasil p 0,017 (p<0,05), artinya memiliki hubungan yang signifikan. Sedangkan rasionalitas penggunaan terapi cairan terhadap jumlah trombosit dengan uji chi-square mendapatkan hasil p 0,021 (p<0,05), artinya memiliki hubungan yang signifikan.

Kata kunci: Demam Berdarah Dengue, Rasionalitas, Outcome Klinis, Antipiretik- Analgesik, Terapi Cairan

FORMULATION AND TOTAL ANTHOCYANIN EVALUATION OF BATH BOMB PREPARATIONS FROM RED DRAGON FRUIT PEEL (SELENICEREUS MONACANTHUS L.) POWDER

2026-02-13T02:50:49+00:00

ABSTRACT

Red Dragon Fruit Peel (Selenicereus monacanthus L.) is often considered waste, even though it contains bioactive compounds such as anthocyanins with high antioxidant activity. This study aimed to formulate bath bomb preparations from the red dragon fruit peel pollen (Selenicereus monacanthus L.) and to evaluate their physical properties and total anthocyanin content.

The formulations were made with varying pollen concentrations of 5%, 7.5%, and 10%, followed by organoleptic, pH, dissolution time, foam height, stability, and qualitative and quantitative anthocyanin tests using the UV-Vis spectrophotometry method. Organoleptic testing showed that F3 (10%) had the most intense color, characteristic aroma, and solid form. In the pH test, F1 (5%) was the most stable formula and met the bath bomb pH range (8–11). All formulas met the dissolution time requirement (<5 minutes), with F2 (7.5%) showing the most optimal dissolution time among the pollen-containing formulas.

In the foam height test, only F3 (10%) met the foam height criteria. Stability testing using the cycling test method showed that F3 had the best color, shape, and aroma stability over six storage cycles. Determination of total anthocyanin content showed that F3 (10%) had the highest level of 2.504 mg/L. Thus, it can be concluded that increasing pollen concentration enhances anthocyanin content and color stability but may affect pH reduction and foam formation.

Keywords: Red dragon fruit peel; Pollen; Bath bomb; Anthocyanins

Drug Related Problems (Drps) Penggunaan Obat Anti Asma Pada Pasien Pediatri di Klinik ‘X’

2026-02-13T03:58:55+00:00

Asthma is a chronic non-communicable disease, with a high prevalence among children in Indonesia, yet adequate treatment is still low. Unoptimally managed asthma can lead to relapses and reduce patients' quality of life. A crucial aspect of therapy is managing Drug-Related Problems (DRPs) in pediatric patients, who have different physiological characteristics than adults.

This study aimed to determine the incidence and categories of DRPs based on the Cipolle classification: requiring additional medication, medication without indication, too high a dose, and too low a dose. This study used a descriptive, observational method with a retrospective approach, utilizing secondary data in the form of medical records of pediatric patients diagnosed with asthma from January to December 2024. Sampling was carried out using purposive sampling with a sample size of 101 patients with inclusion criteria. Data analysis was conducted descriptively to obtain the frequency and percentage of DRPs.

The incidence of DRPs in pediatric patients with asthma was quite significant, with the most common DRPs being the need for additional medication, followed by too low a dose, then medication without an indication, and finally, too high a dose. Patient characteristics showed a predominance of male gender (60%), and the largest age group was 3–5 years (29.09%). The most common comorbidities were rhinitis (38.98%) and acute respiratory infections (ARI) (28.81%).

FORMULASI DAN UJIANTIINFLAMASI SALEP EKSTRAK RESIN JERNANG (Daemonorops Draco (Wild)) Blume PADA MENCIT JANTAN PUTIH(Wistar).

2026-02-13T02:53:02+00:00

Jernang sap (Daemonorops draco (Willd.) Blume) is the exudate of the jernang rattan fruit which has been traditionally used as a traditional medicine. The active compounds contained in it include flavonoids, saponins, terpenoids, alkaloids, and phenolics, which are known to have potential as anti-inflammatory agents. This study aims to design a topical preparation in the form of an ointment from jernang sap extract and to test its physical quality and anti-inflammatory effects in vivo. The extraction process was carried out using a maceration technique using 96% ethanol, then the extract obtained was formulated into three variations of ointment with different concentrations (F1: 1%, F2: 2%, F3: 3%), using a base of vaseline flavum, lanolin, and propyl paraben as a preservative. Testing the physical quality of the ointment included organoleptic examination, homogeneity, pH value, spreadability, and viscosity. Anti-inflammatory activity was tested using male mice (Mus musculus) induced with 1% carrageenan on the paws, and the edema volume was measured using a plethysmometer.

The results showed that an ointment made from jernang extract could be prepared with stable physical properties during storage. ANOVA analysis and further testing showed that formulas with higher concentrations (F2 and F3) provided a significant inflammation-inhibiting effect, nearly comparable to the positive control, a 2.5% hydrocortisone ointment. Thus, jernang extract has potential as a natural ingredient for topical anti-inflammatory ointments.

UJI AKTIVITAS ANTIHIPERURISEMIA EKSTRAK ETANOL DAUN BUNI (Antidesma bunius L.) PADA MENCIT PUTIH (Mus musculus L.) JANTAN

2026-02-13T03:56:32+00:00

Hyperuricemia is a condition characterized by elevated levels of uric acid in the blood, which can lead to diseases such as gout arthritis. This study aims to evaluate the activity and effective dose of ethanolic extract of buni leaves as ananti-hyperuricemic agent in male white mice (Mus musculus L.) induced with potassium oxonate and chicken liver juice. A total of 25 mice were divided into five groups: positive control (allopurinol 100 mg/kgBW), negative control (0.5% Na-CMC), and three test groups receiving buni leaf extract at doses of 50 mg/kgBW, 75 mg/kgBW, and 100 mg/kgBW,respectively. Uric acid levels were measured over a period of 4 hours after treatment. The results showed that the positivecontrol group and all groups treated with buni leaf extract at doses of 50, 75, and 100 mg/kg BW exhibited antihyperuricemic activity, as indicated by a significant difference compared to the negative control group (p<0.05). Thepercentage of antihyperuricemic activity reached 100% in the positive control group and all buni leaf extract groups. It can thus be concluded that the ethanolic extract of buni leaves has potential as an antihyperuricemic agent.

Keywords: Buni leaves (Antidesma bunius L.), anti-hyperuricemia, uric acid, mice (Mus musculus).

PENGARUH PENGENCERAN NANOKOLOID PERAK HASIL BIOSINTESIS MENGGUNAKAN EKSTRAK TANAMAN KELADI SARAWAK (Alocasia macrorrhizos (L.)) SEBAGAI BAHAN AKTIF GEL MELAWAN Staphylococcus aureus

2026-02-13T02:53:39+00:00

The study on evaluate the effect of dilution concentration of silver nanocolloids synthesized using Alocasia macrorrhizos (L.)) extract as the active ingredient in gel formulations on their antibacterial activity against Staphylococcus aureus has been conducted. The gel with undiluted nanocolloid was compared with the previous formulation containing 50% diluted nanocolloid. The gel was formulated using a Carbopol 940 base and evaluated for organoleptic properties, pH, homogeneity, viscosity, spreadability, and hedonic acceptance. Antibacterial activity was assessed using the disk diffusion method. The results showed that the gel met all physical parameters except viscosity. The antibacterial activity against Staphylococcus aureus was categorized as strong, with inhibition zones of 11.52 ± 0.10 mm (F1), 11.83 ± 0.19 mm (F2), and 12.44 ± 0.65 mm (F3). Increasing the nanocolloid concentration from 50% to 100% did not produce a significant difference in antibacterial activity.

A ANTIOXIDANT ACTIVITY TEST OF LOTION FROM ETHANOL FRACTION OF NIPAH LEAVES (Nypa fruticans Wurmb.)

2026-02-13T02:54:15+00:00

The skin is the outermost part of the body and is vulnerable to damage caused by free radicals. One way to protect the skin is through topical preparations such as lotion containing natural antioxidants. This study aimed to determine the antioxidant activity of lotion containing the ethanol fraction of nipah leaves and to identify its IC₅₀ value as an indicator of potency. The ethanol fraction was obtained by maceration and liquid-liquid fractionation, and formulated into three lotion variants with different cetyl alcohol concentrations. Antioxidant activity was tested using the DPPH method and analyzed by UV-Vis spectrophotometry. The results showed that the lotion formula with the highest cetyl alcohol concentration (F3) had an IC₅₀ value of 45.39 µg/mL, categorized as very strong. The conclusion is that lotion with ethanol fraction of nipah leaves has high antioxidant activity and potential as a natural cosmetic product.